Full-length structures


Liu F, et al.  Molecular Structure of the Human CFTR Ion Channel.  Cell. 2017 Mar 23;169(1):85-95.e8.


Zhang Z, Chen J. Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator. Cell. 2016 Dec 1;167(6):1586-1597.e9.


NBD structures 


Mendoza JL, et al. Requirements for efficient correction of ΔF508 CFTR revealed by analyses of evolved sequences.  Cell. 2012 Jan 20;148(1-2):164-74.


Atwell S, et al.  Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.  Protein Eng Des Sel. 2010 May;23(5):375-84. 


Thibodeau PH, Brautigam CA, Machius M, Thomas PJ.  Side chain and backbone contributions of Phe508 to CFTR folding.  Nat Struct Mol Biol. 2005 Jan;12(1):10-6.


Lewis HA, et al.  Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure.  J Biol Chem. 2005 Jan 14;280(2):1346-53.


Lewis HA, et al.  Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.  EMBO J. 2004 Jan 28;23(2):282-93.




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© 2019 CFTR 3D-Structure Consortium; Updated October 7, 2019