Structures of CFTR

A combination of experimental and theoretical approaches have been utilized to generate structures of CFTR.  Experimentally, X-ray crystallographic and NMR studies provide structural and biophysical information about the isolated NBDs.  Cryo-EM has been utilized to generate maps and structures of full-length CFTR.  In addition, multiple labs have utilized computational and theoretical approaches to build homology models of full-length CFTR and to simulate its conformational movements.  

 

The links at left provide access to structures and simulations that have been generated within the Consortium, by other members of the CF research community and by others in the ABC-transporter research field.  

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© 2017 CFTR 3D-Structure Consortium; Updated July 25, 2017