NBD1 Structures

Both murine and human NBD1 structures have been solved using X-ray crystallography.  

 

The multiple NBD variants are listed below with links to their respective PDB files and published manuscripts.  

PDB Code Species Author (Lab)

Notes

Links

 

1R0X

Mouse Lewis (SGX) WT PDB, PubMed  
1R0W Mouse Lewis (SGX) WT PDB, PubMed  
1Q3H Mouse Lewis (SGX) WT PDB, PubMed  
1R10 Mouse Lewis (SGX) WT PDB, PubMed  
1R0Y Mouse Lewis (SGX) WT PDB, PubMed  
1R0Z Mouse Lewis (SGX) WT PDB, PubMed  
1XF9 Mouse Thibodeau (Thomas) F508S PDB, PubMed  
1XFA Mouse Thibodeau (Thomas) F508R PDB, PubMed  
3SI7 Mouse Mendoza (Thomas) F508del PDB, PubMed  
           
1XMI Human Lewis (SGX) F508A* PDB, PubMed  
1XMJ Human Lewis (SGX) F508del* PDB, PubMed  
2BBT Human Lewis (SGX) F508del* PDB, Pubmed  
2BB0 Human Lewis (SGX) WT* PDB, PubMed  
2BBS Human Lewis (SGX) F508del* PDB, PubMed  
2PZE Human Atwell (SGX) [delta]RI PDB, PubMed  
2PZF Human

Atwell (SGX)

WT* PDB, PubMed  
2PZG Human Atwell (SGX) WT* PDB, PubMed  
4WZ6 Human Hall (Aulabaugh)  WT* PDB, PubMed  
5TF7 Human  Chi (Hunt) WT*, ddNTPs

PDB,

PubMed

Additional related PDBs available
6GJS Human Sigoillot (Govaerts) Nanobodies

PDB,

PubMed

Additional related PDBs available

* These proteins are engineered and include additional mutations that increase protein solubility and/or stability.  

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© 2019 CFTR 3D-Structure Consortium; Updated October 7, 2019