To date, experimental structures of full-length CFTR have been solved using electron microscopy approaches. In addition, multiple homology models, based on x-ray structures of homologous ABC-transproter proteins have been generated.
Links to the available structures and homology models are listed below.
|Human||Rosenberg (Ford)||WT||EMDB, PubMed|
|Zebrafish||Zhang (Chen)||WT, apo||EMDB, PDB, PubMed|
|Human||Liu (Chen)||WT, apo||EMDB, PDB, PubMed|
|Zebrafish||Zhang (Chen)||E1372Q, ATP||EMDB, PDB, PubMed|
|Chicken||Fay (Riordan/Chen)||Stabilized||EMDB, PDB, PubMed|
|Human||Zhang (Chen)||E1371Q, ATP||EMDB, PDB, PubMed|
|Human||Liu (Chen)||Ivacaftor||EMDB, PDB, PubMed|
|Human||Liu (Chen)||GLPG1837||EMDB, PDB, PubMed|