Full-length CFTR

To date, experimental structures of full-length CFTR have been solved using electron microscopy approaches.  In addition, multiple homology models, based on x-ray structures of homologous ABC-transproter proteins have been generated.  

 

Links to the available structures and homology models are listed below.  

Cryo-EM Structures

Species Author (Lab)

Notes

Links

Human Rosenberg (Ford) WT EMDB, PubMed
Zebrafish Zhang (Chen) WT, apo EMDB, PDB, PubMed
Human Liu (Chen) WT, apo EMDB, PDB, PubMed
Zebrafish Zhang (Chen) E1372Q, ATP EMDB, PDB, PubMed
Chicken Fay (Riordan/Chen) Stabilized EMDB, PDB, PubMed
Human Zhang (Chen) E1371Q, ATP EMDB, PDB, PubMed
Human Liu (Chen) Ivacaftor EMDB, PDB, PubMed
Human Liu (Chen) GLPG1837 EMDB, PDB, PubMed

 

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© 2019 CFTR 3D-Structure Consortium; Updated October 7, 2019