Homologous ABC proteins

CFTR is a member of the ABC-transporter family of proteins, 48 of which are found in humans.  Numerous structures of homologous proteins have been solved experimentally and provide a framework for understanding the conformational and functional dynamics of the family.  The ensemble of structures solved to date provide critical information about the ATP-regulated movements of the NBDs and TMDs.  

 

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© 2017 CFTR 3D-Structure Consortium; Updated July 25, 2017