NBD1 Structures

Both murine and human NBD1 structures have been solved using X-ray crystallography.  

 

The multiple NBD variants are listed below with links to their respective PDB files and published manuscripts.  

PDB Code Species Author (Lab)

Notes

Links

1R0X

Mouse Lewis (SGX) WT PDB, PubMed
1R0W Mouse Lewis (SGX) WT PDB, PubMed
1Q3H Mouse Lewis (SGX) WT PDB, PubMed
1R10 Mouse Lewis (SGX) WT PDB, PubMed
1R0Y Mouse Lewis (SGX) WT PDB, PubMed
1R0Z Mouse Lewis (SGX) WT PDB, PubMed
1XF9 Mouse Thibodeau (Thomas) F508S PDB, PubMed
1XFA Mouse Thibodeau (Thomas) F508R PDB, PubMed
3SI7 Mouse Mendoza (Thomas) F508del PDB, PubMed
         
1XMI Human Lewis (SGX) F508A* PDB, PubMed
1XMJ Human Lewis (SGX) F508del* PDB, PubMed
2BBT Human Lewis (SGX) F508del* PDB, Pubmed
2BB0 Human Lewis (SGX) WT* PDB, PubMed
2BBS Human Lewis (SGX) F508del* PDB, PubMed
2PZE Human Atwell (SGX) [delta]RI PDB, PubMed
2PZF Human

Atwell (SGX)

WT* PDB, PubMed
2PZG Human Atwell (SGX) WT* PDB, PubMed
4WZ6 Human Hall (Aulabaugh)  WT* PDB, PubMed

* These proteins are engineered and include additioanl mutations that increase protein solubility and/or stability.  

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© 2017 CFTR 3D-Structure Consortium; Updated July 25, 2017